Role of Anticipation and Prediction in Smooth Pursuit Eye Movement Control in Parkinson's Disease
Identifieur interne : 000F95 ( Main/Exploration ); précédent : 000F94; suivant : 000F96Role of Anticipation and Prediction in Smooth Pursuit Eye Movement Control in Parkinson's Disease
Auteurs : Christoph Helmchen [Allemagne] ; Jonas Pohlmann [Allemagne] ; Peter Trillenberg [Allemagne] ; Rebekka Lencer [Allemagne] ; Julia Graf [Allemagne] ; Andreas Sprenger [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Patients with Parkinson's disease (PD) have difficulties in the control of self-guided (i.e., internally driven) movements. The basal ganglia provide a nonspecific internal cue for the development of a preparatory activity for a given movement in the sequence of repetitive movements. Controversy surrounds the question of whether PD patients are capable of (1) anticipating (before an external trigger appears; i.e., anticipation) and (2) predicting movement velocity once a moving target shortly disappears from the visual scene (i.e., prediction). To dissociate between these two components, we examined internally driven (extraretinal generated) smooth pursuit eye movements in PD patients and age-matched healthy controls by systematically varying target blanking periods of a trapezoidally moving target in four paradigms (initial blanking, midramp blanking, blanking after a short ramp, and no blanking). Compared to controls, PD patients showed (1) decreased smooth pursuit gain (without blanking), (2) deficient anticipatory pursuit (prolonged pursuit initiation latency ; reduced eye velocity before target onset in the early onset blanking paradigm), and (3) preserved extraretinal predictive pursuit velocity (midramp target blanking). Deficient anticipation of future target motion was not related to either disease duration or the general motor impairment (UPDRS). We conclude that PD patients have difficulties in anticipating future target motion, which may play a role for the mechanisms involved in deficient gait initiation and termination of PD. In contrast, they remain unimpaired in their capacity of building up an internal representation of continuous target motion. This may explain the clinical advantage of medical devices that use visual motion to improve gait initiation (e.g., "PD glasses").
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000138
- to stream PascalFrancis, to step Curation: 002B76
- to stream PascalFrancis, to step Checkpoint: 000068
- to stream Main, to step Merge: 001047
- to stream Main, to step Curation: 000F95
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Role of Anticipation and Prediction in Smooth Pursuit Eye Movement Control in Parkinson's Disease</title><author><name sortKey="Helmchen, Christoph" sort="Helmchen, Christoph" uniqKey="Helmchen C" first="Christoph" last="Helmchen">Christoph Helmchen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Pohlmann, Jonas" sort="Pohlmann, Jonas" uniqKey="Pohlmann J" first="Jonas" last="Pohlmann">Jonas Pohlmann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Trillenberg, Peter" sort="Trillenberg, Peter" uniqKey="Trillenberg P" first="Peter" last="Trillenberg">Peter Trillenberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lencer, Rebekka" sort="Lencer, Rebekka" uniqKey="Lencer R" first="Rebekka" last="Lencer">Rebekka Lencer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clinical and Molecular Neurogenetics, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Sprenger, Andreas" sort="Sprenger, Andreas" uniqKey="Sprenger A" first="Andreas" last="Sprenger">Andreas Sprenger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0315944</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0315944 INIST</idno><idno type="RBID">Pascal:12-0315944</idno><idno type="wicri:Area/PascalFrancis/Corpus">000138</idno><idno type="wicri:Area/PascalFrancis/Curation">002B76</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000068</idno><idno type="wicri:doubleKey">0885-3185:2012:Helmchen C:role:of:anticipation</idno><idno type="wicri:Area/Main/Merge">001047</idno><idno type="wicri:Area/Main/Curation">000F95</idno><idno type="wicri:Area/Main/Exploration">000F95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Role of Anticipation and Prediction in Smooth Pursuit Eye Movement Control in Parkinson's Disease</title><author><name sortKey="Helmchen, Christoph" sort="Helmchen, Christoph" uniqKey="Helmchen C" first="Christoph" last="Helmchen">Christoph Helmchen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Pohlmann, Jonas" sort="Pohlmann, Jonas" uniqKey="Pohlmann J" first="Jonas" last="Pohlmann">Jonas Pohlmann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Trillenberg, Peter" sort="Trillenberg, Peter" uniqKey="Trillenberg P" first="Peter" last="Trillenberg">Peter Trillenberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lencer, Rebekka" sort="Lencer, Rebekka" uniqKey="Lencer R" first="Rebekka" last="Lencer">Rebekka Lencer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Section of Clinical and Molecular Neurogenetics, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Sprenger, Andreas" sort="Sprenger, Andreas" uniqKey="Sprenger A" first="Andreas" last="Sprenger">Andreas Sprenger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticipation</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Prediction</term><term>Pursuit eye movement</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Anticipation</term><term>Prédiction</term><term>Mouvement oculaire poursuite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) have difficulties in the control of self-guided (i.e., internally driven) movements. The basal ganglia provide a nonspecific internal cue for the development of a preparatory activity for a given movement in the sequence of repetitive movements. Controversy surrounds the question of whether PD patients are capable of (1) anticipating (before an external trigger appears; i.e., anticipation) and (2) predicting movement velocity once a moving target shortly disappears from the visual scene (i.e., prediction). To dissociate between these two components, we examined internally driven (extraretinal generated) smooth pursuit eye movements in PD patients and age-matched healthy controls by systematically varying target blanking periods of a trapezoidally moving target in four paradigms (initial blanking, midramp blanking, blanking after a short ramp, and no blanking). Compared to controls, PD patients showed (1) decreased smooth pursuit gain (without blanking), (2) deficient anticipatory pursuit (prolonged pursuit initiation latency ; reduced eye velocity before target onset in the early onset blanking paradigm), and (3) preserved extraretinal predictive pursuit velocity (midramp target blanking). Deficient anticipation of future target motion was not related to either disease duration or the general motor impairment (UPDRS). We conclude that PD patients have difficulties in anticipating future target motion, which may play a role for the mechanisms involved in deficient gait initiation and termination of PD. In contrast, they remain unimpaired in their capacity of building up an internal representation of continuous target motion. This may explain the clinical advantage of medical devices that use visual motion to improve gait initiation (e.g., "PD glasses").</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Helmchen, Christoph" sort="Helmchen, Christoph" uniqKey="Helmchen C" first="Christoph" last="Helmchen">Christoph Helmchen</name></noRegion><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name><name sortKey="Lencer, Rebekka" sort="Lencer, Rebekka" uniqKey="Lencer R" first="Rebekka" last="Lencer">Rebekka Lencer</name><name sortKey="Pohlmann, Jonas" sort="Pohlmann, Jonas" uniqKey="Pohlmann J" first="Jonas" last="Pohlmann">Jonas Pohlmann</name><name sortKey="Sprenger, Andreas" sort="Sprenger, Andreas" uniqKey="Sprenger A" first="Andreas" last="Sprenger">Andreas Sprenger</name><name sortKey="Trillenberg, Peter" sort="Trillenberg, Peter" uniqKey="Trillenberg P" first="Peter" last="Trillenberg">Peter Trillenberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F95 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F95 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0315944
|texte= Role of Anticipation and Prediction in Smooth Pursuit Eye Movement Control in Parkinson's Disease
}}
| This area was generated with Dilib version V0.6.23. |  |